The invention provides systems and methods for an autonomous vehicle (AV) control system comprising an onboard unit (OBU) and a roadside unit (RSU), which are two components of an Intelligent Road Infrastructure System (IRIS). This integrated vehicle-road system provides sensing, prediction, decision-making, and control instructions for specific vehicles at a microscopic level. Specifically, through the AV control system, an AV can be effectively and efficiently controlled by the AV itself and/or by the RSU. The AV control system provides individual vehicles with detailed time-sensitive control instructions for vehicles to fulfill driving tasks. In addition, the RSU conducts behavior prediction for individual vehicles at a microscopic level from 1 to 10 milliseconds, which is critical for connected and automated vehicle (CAV) operations.