- 专利标题： Compositions and methods for inhibiting expression of RRM2 genes
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申请号： US16846535申请日： 2020-04-13
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公开(公告)号： US11920134B2公开(公告)日： 2024-03-05
- 发明人: John Frederick Boylan , Birgit Bramlage , Markus Hossbach , John Reidhaar-Olson
- 申请人： Arrowhead Pharmaceuticals, Inc.
- 申请人地址： US CA Pasadena
- 专利权人： Arrowhead Pharmaceuticals, Inc.
- 当前专利权人： Arrowhead Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Pasadena
- 代理商 Paul VanderVelde; Robert M. Teigen; Meibo Chen
- 优先权： EP 187851 2010.10.18
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A01K67/00 ; A61K48/00 ; C12N9/02
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.
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