- 专利标题： Bisphenol derivatives and their use as androgen receptor activity modulators
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申请号： US17404589申请日： 2021-08-17
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公开(公告)号： US11919874B2公开(公告)日： 2024-03-05
- 发明人: Raymond J. Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Nasrin R. Mawji , Jun Wang , Carmen Adriana Banuelos , Yu-Chi Yang
- 申请人： The University of British Columbia , Provincial Health Services Authority
- 申请人地址： CA Vancouver
- 专利权人： The University of British Columbia,Provincial Health Services Authority
- 当前专利权人： The University of British Columbia,Provincial Health Services Authority
- 当前专利权人地址： CA Vancouver; CA Vancouver
- 代理机构： COOLEY LLP
- 分案原申请号： US16848061 2020.04.14
- 主分类号： C07D295/088
- IPC分类号： C07D295/088 ; A61K31/09 ; A61K31/10 ; A61K31/145 ; A61K31/4164 ; A61K31/5375 ; A61K45/06 ; C07C43/23 ; C07C69/28 ; C07C233/18 ; C07C311/04 ; C07C311/51 ; C07C317/18 ; C07C317/22 ; C07C317/28 ; C07D233/60
摘要：
Compounds having a structure of Formula I:
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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