A staple cartridge for use with a surgical instrument that includes a cartridge body, a longitudinal row of first staple cavities, a longitudinal row of second staple cavities, a third staple cavity, a first staple driver and a second staple driver. The cartridge body has a longitudinal slot that defines a longitudinal axis. The first and second longitudinal rows of staple cavities are obliquely-oriented relative to the longitudinal axis and a third staple cavity is positioned substantially parallel to the longitudinal axis. The staple cavities positioned in the first and second rows are configured to receive staples. The first and second staple drivers include staple supports and ramps. The first ramp of the first staple driver is positioned beneath at least one first staple support and the second ramp is laterally offset relative to the second staple support.