An electronic device may include a housing and a PhotoPlethysmoGram (PPG) sensor disposed inside the housing. The PPG sensor may include a first Light Emitting Diode (LED) configured to generate light in a first wavelength band, a second LED configured to generate light in a second wavelength band, a third LED configured to generate light in a third wavelength band, a fourth LED configured to generate light in a fourth wavelength band, and a light receiving module including at least one photo diode. The electronic device may include a processor operatively coupled with the PPG sensor and a memory operatively coupled with the processor. The memory may include instructions that, when executed, cause the processor to measure optical densities of the light generated by the first LED to the fourth LED, and calculate a blood glucose value based at least in part on the measured optical densities.