An electronic device is provided. The electronic device includes a housing, a plurality of first antennas, at least one second antenna, at least one sensor, and at least one processor. The at least one processor is configured to perform a multi input multi output (MIMO) operation by using the plurality of first antennas in first status, detect that the electronic device in the first status is changed to be in second status, by folding or sliding of at least one of the first housing or the second housing, and disable at least one, which is adjacent to the at least one second antenna, of the plurality of first antennas and perform a single input single output (SISO) operation by using remaining antennas of the plurality of first antennas, when a frequency band or a channel of a signal transmitted by the plurality of first antennas is adjacent to or partially overlapped with that of a signal received by the at least one second antenna.