A wireless transmit receive unit (WTRU) may be configured to transmit uplink control information such as Hybrid Automatic Retransmission Request (HARQ) Acknowledgement or Negative Acknowledgement (ACK/NACK) using a sequence. The HARQ ACK/NACK may comprise one bit or two bits of information, and the WTRU may use a cyclic shift of the sequence to transmit the HARQ ACK/NACK. The WTRU may use different cyclic shifts of the sequence to transmit different HARQ ACK/NACK values and the cyclic shifts may be separated from each other in a manner to facilitate the transmissions. The WTRU may be further configured to receive, from a physical downlink control channel (PDCCH), an indication of a resource block for transmitting the HARQ ACK/NACK.