A Computer Aided Diagnosis, CADx, system (200) is described that comprises: at least one input (210, 212, 214) configured to provide at least one input medical image; and a CADx processing engine (220) configured to receive and process the at least one input medical image and produce at least one CADx score. A CADx score mapping circuit is operably coupled to the CADx processing engine (220) and configured to: map the at least one CADx score to a risk adjusted virtual score; and generate an output (235) of at least the risk adjusted virtual score associated with the processed at least one input medical image. The at least one CADx score and the risk adjusted virtual score correspond to an equivalent risk of condition or disease associated with a patient.