发明授权
- 专利标题： Chimeric antigen receptor cells targeting ROBO1, preparation method and use thereof
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申请号： US16700401申请日： 2019-12-02
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公开(公告)号： US11697685B2公开(公告)日： 2023-07-11
- 发明人: Huashun Li , Baolei Wang , Kunkun Han
- 申请人： Asclepius (Suzhou) Technology Company Group Co., Ltd.
- 申请人地址： CN Suzhou
- 专利权人： Asclepius (Suzhou) Technology Company Group Co., Ltd.
- 当前专利权人： Asclepius (Suzhou) Technology Company Group Co., Ltd.
- 当前专利权人地址： CN Suzhou
- 代理机构： Flener IP & Business Law
- 代理商 Zareefa B. Flener
- 优先权： CN 1710407619.8 2017.06.02
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K14/705 ; C12N5/0783 ; A61K35/17 ; A61P35/00 ; C07K14/725 ; C12N15/867 ; A61K38/00 ; A61K39/00
摘要：
The present invention relates to chimeric antigen receptor cells targeting ROBO1, in particular, enhanced CAR-T cells and CAR-NK cells targeting ROBO1, and preparation and application thereof. The cells can stably expressing CAR elements, while secreting extracellular domain molecules expressing PD-1 protein or mutants thereof, and thus may block PD-11PD-L1 molecular interaction. It has been found through animal experiments that the cells have very good anti-tumor effects, and the above-mentioned cells can significantly reduce tumor recurrence and improve the survival rate compared with the conventional ROBO1-targeted CAR modified cells.
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