- 专利标题： Nanoparticle to target cancer
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申请号： US17555285申请日： 2021-12-17
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公开(公告)号： US11696922B2公开(公告)日： 2023-07-11
- 发明人: Jill P. Smith , Stephan Stern , Abdullah Mahmud
- 申请人： Georgetown University , The United States of America, as represented by the Secretary, Department of Health & Human Services
- 申请人地址： US DC Washington
- 专利权人： Georgetown University,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： Georgetown University,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington; US MD Bethesda
- 代理机构： Klarquist Sparkman, LLP
- 分案原申请号： US16084942
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; A61K31/7088 ; C12N15/115 ; A61K47/10 ; A61K47/18 ; A61K9/107 ; A61K9/51 ; C12N15/11 ; A61K47/60 ; A61K47/64 ; A61K47/69 ; A61K31/713 ; C12N15/113 ; A61P35/00 ; A61K9/127 ; B82Y5/00
摘要：
A construct, or a pharmaceutically acceptable salt thereof, comprising:
(a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized;
(b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and
(c) a siRNA complexed with the poly(L-lysine) of the polymer moiety,
wherein the construct is neutralized.
(a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized;
(b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and
(c) a siRNA complexed with the poly(L-lysine) of the polymer moiety,
wherein the construct is neutralized.
公开/授权文献
- US20220211738A1 NANOPARTICLE TO TARGET CANCER 公开/授权日：2022-07-07
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