公开(公告)号：US11246881B2

公开(公告)日：2022-02-15

申请号：US16084942

申请日：2017-03-15

申请人： Georgetown University ,  The United States of America, as represented by the Secretary, Department of Health & Human Services

发明人： Jill P. Smith ,  Stephan Stern ,  Abdullah Mahmud

IPC分类号： C07H21/02 ,  A61K48/00 ,  A61K31/7088 ,  C12N15/115 ,  A61K47/10 ,  A61K47/18 ,  A61K9/107 ,  A61K9/51 ,  C12N15/11 ,  A61K47/60 ,  A61K47/64 ,  A61K47/69 ,  A61K31/713 ,  A61P35/00 ,  A61K9/127 ,  B82Y5/00

摘要： A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.

公开(公告)号：US20190076457A1

公开(公告)日：2019-03-14

申请号：US16084942

申请日：2017-03-15

申请人： Georgetown University ,  The United States of America, as represented by the Secretary, Department of Health & Human Servic

发明人： Jill P. Smith ,  Stephan Stern ,  Abdullah Mahmud

IPC分类号： A61K31/7088 ,  A61K9/127 ,  A61P35/00 ,  C12N15/115 ,  A61K47/60 ,  A61K47/64 ,  A61K47/69 ,  C12N15/11 ,  A61K47/10 ,  A61K47/18 ,  A61K9/107 ,  B82Y5/00 ,  A61K9/51

摘要： A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.

公开(公告)号：US11696922B2

公开(公告)日：2023-07-11

申请号：US17555285

申请日：2021-12-17

申请人： Georgetown University ,  The United States of America, as represented by the Secretary, Department of Health & Human Services

发明人： Jill P. Smith ,  Stephan Stern ,  Abdullah Mahmud

IPC分类号： C07H21/02 ,  A61K31/7088 ,  C12N15/115 ,  A61K47/10 ,  A61K47/18 ,  A61K9/107 ,  A61K9/51 ,  C12N15/11 ,  A61K47/60 ,  A61K47/64 ,  A61K47/69 ,  A61K31/713 ,  C12N15/113 ,  A61P35/00 ,  A61K9/127 ,  B82Y5/00

CPC分类号： A61K31/7088 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/5146 ,  A61K31/713 ,  A61K47/10 ,  A61K47/183 ,  A61K47/60 ,  A61K47/6455 ,  A61K47/6935 ,  A61P35/00 ,  B82Y5/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/115 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2320/30 ,  C12N2320/32

摘要： A construct, or a pharmaceutically acceptable salt thereof, comprising:



(a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized;
(b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and
(c) a siRNA complexed with the poly(L-lysine) of the polymer moiety,
wherein the construct is neutralized.