- 专利标题： Method of eliciting a CD8+ cytotoxic response in hepatocellular carcinoma patients with a population of activated T cells
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申请号： US17852623申请日： 2022-06-29
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公开(公告)号： US11672848B2公开(公告)日： 2023-06-13
- 发明人: Toni Weinschenk , Andrea Mahr , Jens Fritsche , Phillip Mueller , Anita Wiebe , Sarah Kutscher
- 申请人： Immatics Biotechnologies GmbH
- 申请人地址： DE Tuebingen
- 专利权人： IMMATICS BIOTECHNOLOGIES GMBH
- 当前专利权人： IMMATICS BIOTECHNOLOGIES GMBH
- 当前专利权人地址： DE Tuebingen
- 代理机构： McBee Moore & Vanik IP, LLC
- 优先权： GB 23016 2014.12.23 GB 01017 2015.01.21
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61K39/00 ; A61K38/04 ; C07K7/00 ; C07K7/06 ; C07K7/08 ; C07K14/435 ; C07K14/725 ; C07K14/74 ; C07K16/18 ; C12N5/0783 ; C12N15/115 ; G01N33/68 ; A61K51/10 ; A61K35/12
摘要：
A method of eliciting an immune response in a patient who has a cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize the cancer cells in the patient that aberrantly express a peptide consisting of the amino acid sequence of ALVEQGFTV (SEQ ID NO: 5), in which the peptide is in a complex with an MHC molecule.
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