A modular vision system that can include a housing with a faceplate and a first and second optical module mounted to the faceplate. Each of the first and second optical modules can include a mounting body, a rectangular image sensor, and an imaging lens that defines an optical axis and a field of view. The first optical module can be configured to be mounted to the faceplate in a first plurality of mounting orientations and the second optical module can be configured to be mounted to the faceplate in a second plurality of mounting orientations. The first and second optical modules can thus collectively provide a plurality of imaging configurations.