Invention Grant
- Patent Title: Substituted 4-phenylpiperidines, their preparation and use
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Application No.: US17099231Application Date: 2020-11-16
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Publication No.: US11649240B2Publication Date: 2023-05-16
- Inventor: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agent Gary J. Gershik
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04
Abstract:
The present invention provides a compound having the structure:
wherein
R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl,
wherein two or more of R1, R2, R3, R4, or R5 are other than H;
R6 is H, OH, or halogen; and
B is a substituted or unsubstituted heterobicycle,
wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than
or a pharmaceutically acceptable salt thereof.
wherein
R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl,
wherein two or more of R1, R2, R3, R4, or R5 are other than H;
R6 is H, OH, or halogen; and
B is a substituted or unsubstituted heterobicycle,
wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than
or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20210214360A1 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE Public/Granted day:2021-07-15
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