Technologies for secure I/O include a compute device, which further includes a processor, a memory, a trusted execution environment (TEE), one or more input/output (I/O) devices, and an I/O subsystem. The I/O subsystem includes a device memory access table (DMAT) programmed by the TEE to establish bindings between the TEE and one or more I/O devices that the TEE trusts and a memory ownership table (MOT) programmed by the TEE when a memory page is allocated to the TEE.