A networked system includes an application that produces application frames at a first application frame rate, a graphics processing system that processes the application frames to produce graphics frames at a first graphics frame rate, a VDI system that processes the graphics frames to produce VDI frames at a first VDI frame rate, and an endpoint device that processes the VDI frames to produce endpoint frames at an endpoint frame rate. A frame rate optimization system monitors the application processing, the graphics processing, the VDI processing, and the endpoint processing and, based on the endpoint frame rate, reconfigures at least one of: the application to produce the application frames at a second application frame rate, the graphics processing system to produce the graphics frames at a second graphics frame rate, or the VDI system to produce the VDI frames at a second VDI frame rate.