- 专利标题： Method for efficiently inducing antibody, antibody and detection system for hepatitis virus
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申请号： US16972367申请日： 2019-06-06
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公开(公告)号： US11571473B2公开(公告)日： 2023-02-07
- 发明人: Hisashi Narimatsu , Kiyohiko Angata , Hiroyuki Kaji , Atsushi Kuno , Takashi Sato , Yasunori Chiba , Akira Togayachi , Hiroki Shimizu , Maki Sogabe , Takanori Wagatsuma , Masashi Mizokami , Masaaki Korenaga , Kazuto Tajiri , Tatsuhiko Ozawa
- 申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , UNIVERSITY OF TOYAMA
- 申请人地址： JP Tokyo; JP Toyama
- 专利权人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY,UNIVERSITY OF TOYAMA
- 当前专利权人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY,UNIVERSITY OF TOYAMA
- 当前专利权人地址： JP Tokyo; JP Toyama
- 代理机构： Oliff PLC
- 优先权： JPJP2018-108179 20180606
- 国际申请： PCT/JP2019/022588 WO 20190606
- 国际公布： WO2019/235584 WO 20191212
- 主分类号： A61K39/29
- IPC分类号： A61K39/29 ; C07K14/005 ; A61P31/20 ; C07K16/08 ; G01N33/576 ; A61K39/00
摘要：
An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.
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