Invention Grant
- Patent Title: Isoquinolines as inhibitors of HPK1
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Application No.: US16921297Application Date: 2020-07-06
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Publication No.: US11566003B2Publication Date: 2023-01-31
- Inventor: Bryan Chan , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Michael Lainchbury , Emanuela Gancia , Eileen Seward , Andrew Madin , David Favor , Kin Chiu Fong , Yonghan Hu , Andrew Good
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Priority: WOPCT/CN2017/078790 20170330,WOPCT/CN2018/076908 20180215
- Main IPC: C07D217/22
- IPC: C07D217/22 ; A61K31/549 ; A61P35/00 ; A61K45/06 ; C07D401/04 ; A61K31/4725 ; A61K31/506 ; A61K31/501 ; C07D471/04 ; C07D413/04 ; C07D413/14 ; A61K31/5377 ; C07D417/04 ; A61K31/4985 ; C07D401/14 ; C07D487/04 ; A61K31/551 ; C07D498/04 ; A61K31/5383 ; C07D405/14 ; C07D519/00 ; C07D498/14 ; C07D513/04 ; A61K31/554 ; A61K31/55 ; A61K31/472 ; C07D409/14 ; C07D491/04 ; C07D487/14
Abstract:
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
Public/Granted literature
- US20210163417A1 ISOQUINOLINES AS INHIBITORS OF HPK1 Public/Granted day:2021-06-03
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