- 专利标题： Non-cleavable substance P conjugates and methods of use thereof
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申请号： US15047193申请日： 2016-02-18
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公开(公告)号： US11530243B2公开(公告)日： 2022-12-20
- 发明人: Douglas A Lappi , Brian J Russell , E Denise Higgins
- 申请人： VEIOVE ANIMAL HEALTH INC.
- 申请人地址： US CA San Diego
- 专利权人： VEIOVE ANIMAL HEALTH INC.
- 当前专利权人： VEIOVE ANIMAL HEALTH INC.
- 当前专利权人地址： US CA San Diego
- 代理机构： Wilson Sonsini Goodrich & Rosati
- 主分类号： C07K7/22
- IPC分类号： C07K7/22 ; C07K14/415 ; C07K14/00 ; C12N9/52 ; A61K47/64 ; A61K38/00
摘要：
Described herein are methods for treating disorders that relate to neurons that express the neurokinin-1 receptor (NK-1R) in a subject which comprises administering to the subject an effective amount of the pharmaceutical composition of the non-cleavable conjugate comprising a molecule that is recognized and internalized by the NK-1R, and a molecule that is taken inside the cell to kill or temporarily alter the cell.
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