公开(公告)号：US11530243B2

公开(公告)日：2022-12-20

申请号：US15047193

申请日：2016-02-18

申请人： VEIOVE ANIMAL HEALTH INC.

发明人： Douglas A Lappi ,  Brian J Russell ,  E Denise Higgins

IPC分类号： C07K7/22 ,  C07K14/415 ,  C07K14/00 ,  C12N9/52 ,  A61K47/64 ,  A61K38/00

摘要： Described herein are methods for treating disorders that relate to neurons that express the neurokinin-1 receptor (NK-1R) in a subject which comprises administering to the subject an effective amount of the pharmaceutical composition of the non-cleavable conjugate comprising a molecule that is recognized and internalized by the NK-1R, and a molecule that is taken inside the cell to kill or temporarily alter the cell.

公开(公告)号：US20230272008A1

公开(公告)日：2023-08-31

申请号：US17935874

申请日：2022-09-27

申请人： Veiove Animal Health Inc

发明人： Douglas A. LAPPI ,  Brian J. RUSSELL ,  E. Denise HIGGINS

IPC分类号： C07K7/22 ,  C07K14/415 ,  C12N9/52 ,  C07K14/00 ,  A61K47/64

CPC分类号： C07K7/22 ,  A61K47/64 ,  A61K47/6415 ,  C07K14/00 ,  C07K14/415 ,  C12N9/52 ,  C12Y304/24069 ,  A61K38/00

摘要： Described herein are methods for treating disorders that relate to neurons that express the neurokinin-1 receptor (NK-1R) in a subject which comprises administering to the subject an effective amount of the pharmaceutical composition of the non-cleavable conjugate comprising a molecule that is recognized and internalized by the NK-1R, and a molecule that is taken inside the cell to kill or temporarily alter the cell.