- 专利标题： Spiro compounds as inhibitors of KRAS
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申请号： US17153065申请日： 2021-01-20
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公开(公告)号： US11530218B2公开(公告)日： 2022-12-20
- 发明人: Le Zhao , Xiaozhao Wang , Wenyu Zhu , Haolin Yin , Liangxing Wu , Wenqing Yao
- 申请人： Incyte Corporation
- 申请人地址： US DE Wilmington
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： US DE Wilmington
- 代理机构： Lathrop GPM LLP
- 代理商 Brian C. Trinque; Nicole Sassu
- 主分类号： C07D471/20
- IPC分类号： C07D471/20 ; C07D471/22 ; C07D491/20 ; C07D498/20
摘要：
Disclosed are spirocyclic compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and treating cancer, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
公开/授权文献
- US20210230162A1 SPIRO COMPOUNDS AS INHIBITORS OF KRAS 公开/授权日：2021-07-29
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