Methods, systems, articles of manufacture and apparatus to detect process hijacking are disclosed herein. An example apparatus to detect control flow anomalies includes a parsing engine to compare a target instruction pointer (TIP) address to a dynamic link library (DLL) module list, and in response to detecting a match of the TIP address to a DLL in the DLL module list, set a first portion of a normalized TIP address to a value equal to an identifier of the DLL. The example apparatus disclosed herein also includes a DLL entry point analyzer to set a second portion of the normalized TIP address based on a comparison between the TIP address and an entry point of the DLL, and a model compliance engine to generate a flow validity decision based on a comparison between (a) the first and second portion of the normalized TIP address and (b) a control flow integrity model.