- 专利标题: Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
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申请号: US16098341申请日: 2017-05-08
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公开(公告)号: US11352322B2公开(公告)日: 2022-06-07
- 发明人: Sridharan Rajagopal , Mahanandeesha S. Hallur , Purushottam Dewang , Kannan Murugan , Durga Prasanna Kumar C. H. , Pravin Iyer , Chandrika Mulakala , Dhanalakshmi Sivanandhan , Sreekala Nair , Mohd Zainuddin , Subramanyam Janardhan Tantry , Chandru Gajendran , Sriram Rajagopal
- 申请人: Jubilant Epicore LLC
- 申请人地址: US PA Yardley
- 专利权人: Jubilant Epicore LLC
- 当前专利权人: Jubilant Epicore LLC
- 当前专利权人地址: US PA Yardley
- 代理机构: Seed IP Law Group LLP
- 优先权: IN201641016129 20160509
- 国际申请: PCT/IN2017/050167 WO 20170508
- 国际公布: WO2017/195216 WO 20171116
- 主分类号: C07D205/12
- IPC分类号: C07D205/12 ; A61P35/00 ; C07C235/56 ; C07C237/20 ; C07C259/08 ; C07D205/04 ; C07D211/26 ; C07D217/18 ; C07D231/12 ; C07D233/64 ; C07D239/26 ; C07D249/04 ; C07D401/04 ; C07D401/14 ; C07D413/12 ; C07D413/14 ; C07D417/06 ; C07D417/12 ; C07D487/04 ; C07D495/04 ; C07D209/44 ; A61K45/06
摘要:
The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.
公开/授权文献
- US20200308110A1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS 公开/授权日:2020-10-01
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