- 专利标题： PD-1 CAR NK-92 cell and preparation method and use thereof
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申请号： US16389954申请日： 2019-04-21
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公开(公告)号： US11331345B2公开(公告)日： 2022-05-17
- 发明人: Huashun Li , Baolei Wang , Kunkun Han , Baoyong Ren
- 申请人： Asclepius (Suzhou) Technology Company Group Co., Ltd.
- 申请人地址： CN Suzhou
- 专利权人： Asclepius (Suzhou) Technology Company Group Co., Ltd.
- 当前专利权人： Asclepius (Suzhou) Technology Company Group Co., Ltd.
- 当前专利权人地址： CN Suzhou
- 代理机构： Flener IP & Business Law
- 代理商 Zareefa B. Flener
- 优先权： CN201610944672.7 20161026
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K14/47 ; A61P35/00 ; C12N15/86 ; A61K48/00 ; C12N15/62 ; C12N15/867 ; C12N5/10 ; C07K19/00
摘要：
Provided are a PD-1 CAR NK-92 cell and a preparation method and use thereof. The PD-1 CAR NK-92 cell expresses PD-1-CD8™-4-1BB-CD3ζ fusion protein in NK-92 cells. The PD-1 CAR NK-92 is obtained by infecting an NK92 cell line with a PD-1 CAR molecule and obtaining monoclonal cells by means of flow screening, and culturing and expanding CAR NK92 monoclonal cell strains with stable traits and a high killing activity. The cells can be produced on a large scale, can be used in different patients without GVHR rejection, and have a specific killing activity and significant therapeutic effect on tumors.
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