A driver, a display device, and an optical compensation method thereof are provided. The display panel includes sub-pixels arranged in an array. The method includes: receiving an initial gray level of each sub-pixel of a picture to be displayed; determining whether each sub-pixel satisfies a preset determination condition based on the initial gray level of each sub-pixel; if an absolute value of a difference between the initial gray levels of two sub-pixels electrically connected to a same data line and located in two adjacent rows is greater than a preset threshold, it is determined that a sub-pixel in a next row satisfies the preset determination condition; and, in response to determining that a sub-pixel satisfies the preset determination condition, acquiring a first compensation parameter of the sub-pixel, and compensating the initial gray level of the sub-pixel based on the acquired first compensation parameter.