A lesion tracking system is operable to receive a first medical scan and second medical scan associated with a patient ID. A lesion area calculation is performed on a first subset of image slices determined to include a lesion detected in the first medical to generate a first set of lesion area measurements. The lesion area calculation is performed on a second subset of image slices determined to include the lesion in the second medical scan to generate a second set of lesion area measurements. A lesion volume calculation is performed on the first set of lesion area measurements and the second set of lesion area measurements to generate a first lesion volume measurement and a second lesion volume measurement, respectively, and the first and second lesion volume measurements are utilized to calculate a lesion volume change for transmission to a client device for display via a display device.