An OLED drive power supply includes a power supply board connected to a main board and OLED screen, the power supply board includes a power supply circuit, first conversion module, second conversion module and switch; after powering on, the power supply circuit starts the first conversion module to output high-voltage DC to second conversion module, output first voltage and second voltage to power main board, switch converts first voltage to first enabling voltage to power OLED screen; after preset time, main board outputs second enabling signal to power supply circuit, to control second conversion module to start and output second enabling voltage to power and light OLED screen, first conversion module comprises bridgeless PFC circuit and auxiliary path LLC control circuit integrated into same semiconductor chip encapsulation, and omitting specific standby circuit, circuit structure is simplified, area of power supply board is reduced, and production cost is reduced.