Methods, systems and computer program products for dynamically selecting an OSC hazard avoidance mechanism are provided. Aspects include receiving a load instruction that is associated with an operand store compare (OSC) prediction. The OSC prediction is stored in an entry of an OSC history table (OHT) and includes a multiple dependencies indicator (MDI). Responsive to determining the MDI is in a first state, aspects include applying a first OSC hazard avoidance mechanism in relation to the load instruction. Responsive to determining that the load instruction is dependent on more than one store instruction, aspects include placing the MDI in a second state. The MDI being in the second state provides an indication to apply a second OSC hazard avoidance mechanism in relation to the load instruction.