- 专利标题： Methods and compositions for diagnosis and treatment of autoimmune disease secondary to multiple sclerosis by assessing genotypes associated with elevated IL-21
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申请号： US16801009申请日： 2020-02-25
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公开(公告)号： US11243211B2公开(公告)日： 2022-02-08
- 发明人: Alasdair J. Coles , Joanne L. Jones , Alastair Compston
- 申请人： Cambridge Enterprise Limited
- 申请人地址： GB Cambridge
- 专利权人： Cambridge Enterprise Limited
- 当前专利权人： Cambridge Enterprise Limited
- 当前专利权人地址： GB Cambridge
- 代理机构： Steptoe & Johnson LLP
- 代理商 Z. Ying Li; Wyan-Ching M. Lee
- 主分类号： G01N33/564
- IPC分类号： G01N33/564 ; G01N33/68 ; C12Q1/6883 ; C12Q1/6827 ; C12N15/10 ; A61P25/00 ; A61P37/00
摘要：
The invention provides methods of diagnosing and treating multiple sclerosis (MS) patients, including methods of identifying and treating multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. The increased risk may be linked to certain single nucleotide polymorphism genotypes that are indicative of elevated IL-21 levels. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.
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