A guidewire manipulation system may include a cylindrical drum, having a cylindrical outer drum surface with a helical groove for housing a flexible guidewire and an anchoring mechanism for attaching the flexible guidewire to the drum. The system may also include an outer shell or belt disposed around the drum, forming an opening through which the flexible guidewire exits. The system may also include a first actuator coupled with the drum for rotating the drum about a first axis, and a second actuator coupled with the drum for rotating the system about a second axis.