- 专利标题： Hydrocodone base and methods for its purification
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申请号： US16498196申请日： 2018-03-27
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公开(公告)号： US11155548B2公开(公告)日： 2021-10-26
- 发明人: Jessica Cardot , Joshua Sasine , Paul Nichols
- 申请人： Noramco, LLC
- 申请人地址： US DE Wilmington
- 专利权人： Noramco, LLC
- 当前专利权人： Noramco, LLC
- 当前专利权人地址： US DE Wilmington
- 代理机构： Alston & Bird LLP
- 国际申请： PCT/IB2018/052103 WO 20180327
- 国际公布： WO2018/178879 WO 20181004
- 主分类号： C07D489/02
- IPC分类号： C07D489/02 ; C07D471/08 ; C07D489/04
摘要：
A method of recovering a highly pure hydrocodone base from an impure hydrocodone preparation includes contacting the impure hydrocodone preparation with a weak acid in water to form a solution and adding a strong base to the solution in an amount sufficient to precipitate the pure hydrocodone base product. A highly pure hydrocodone base comprises less than 0.0025 wt % codeinone.
公开/授权文献
- US20200031826A1 HYDROCODONE BASE AND METHODS FOR ITS PURIFICATION 公开/授权日：2020-01-30
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