The disclosed technology includes device, systems, and methods for detecting an analyte using a biosensor. In some implementations, the biosensor may be a transdermal biosensor including a housing material, a nanocellulose material disposed within the housing material, an enzyme entrapped within the nanocellulose material that produces a chemical or biological product when exposed to a vapor or liquid, and a luminescent material within the nanocellulose material that emits visible light upon a chemical or biological reaction with the chemical or biological product.