发明授权
- 专利标题： Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
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申请号： US16286075申请日： 2019-02-26
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公开(公告)号： US11078485B2公开(公告)日： 2021-08-03
- 发明人: Charles Allerson , Balkrishen Bhat , Anne B. Eldrup , Muthiah Manoharan , Richard H. Griffey , Brenda F. Baker , Eric E. Swayze
- 申请人： Ionis Pharmaceuticals, Inc.
- 申请人地址： US CA Carlsbad
- 专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： McNeill Baur PLLC
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; C07H21/00 ; C07H21/04 ; C12N15/11 ; A61K48/00 ; C07H21/02
摘要：
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
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