Embodiments are disclosed for health assessment and diagnosis implemented in an artificial intelligence (AI) system. In an embodiment, a method comprises: capturing, using one or more sensors of a device, signals including information about a user's symptoms; using one or more processors of the device to: collect other data correlative of symptoms experienced by the user; and implement pre-trained data driven methods to: determine one or more symptoms of the user; determine a disease or disease state of the user based on the determined one or more symptoms; determine a medication effectiveness in suppressing at least one determined symptom or improving the determined disease state of the user; and present, using an output device, one or more evidence for at least one of the determined symptoms, the disease, disease state, or an indication of the medication effectiveness for the user.