A method for targeted content placement using overlays includes receiving media content from a content feed and displaying the media content from the content feed at a display of the media device. As the display of the media device displays the media content, the method also includes fingerprinting at least one frame of the media content to obtain a fingerprint and identifying an in-frame advertisement based on the obtained fingerprint. The in-frame advertisement corresponds to an advertisement within a portion of the at least one frame. The method further includes determining a target overlay location within the at least one frame with the in-frame advertisement, the target overlay location corresponding to a size of the in-frame advertisement, and superimposing overlay content at the target overlay location when the display of the media device displays the at least one frame with the in-frame advertisement.