- 专利标题: Microbiome-based informed method to formulate live biotherapeutics
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申请号: US16800702申请日: 2020-02-25
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公开(公告)号: US11037655B2公开(公告)日: 2021-06-15
- 发明人: Jacques Ravel , Michael France , Lindsay Rutt , Bing Ma
- 申请人: University of Maryland, Baltimore
- 申请人地址: US MD Baltimore
- 专利权人: University of Maryland, Baltimore
- 当前专利权人: University of Maryland, Baltimore
- 当前专利权人地址: US MD Baltimore
- 代理机构: Sheridan Ross PC
- 主分类号: A61K35/742
- IPC分类号: A61K35/742 ; A61K38/00 ; A61K45/00 ; G16B30/20 ; C12N9/00
摘要:
Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.
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