Systems and methods related to power amplification and power supply control. A method of operating a power amplification control system can include receiving, by an interface, a transceiver control signal from a transceiver. The method can further include generating, by a power amplifier control component, a power amplifier control signal based on the transceiver control signal from the transceiver. The method can also include generating, by a power supply control component, a power supply control signal based on one or more of the transceiver control signal from the transceiver or a local control signal from the power amplifier control component.