- 专利标题： Systems and methods for immobilizing extracellular matrix material on organ on chip, multilayer microfluidics microdevices, and three-dimensional cell culture systems
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申请号： US15748066申请日： 2016-07-27
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公开(公告)号： US11008546B2公开(公告)日： 2021-05-18
- 发明人: Dongeun Huh , Mark Mondrinos , Cassidy Blundell , Jeongyun Seo
- 申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 申请人地址： US PA Philadelphia
- 专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Baker Botts, L.L.P.
- 国际申请： PCT/US2016/044321 WO 20160727
- 国际公布： WO2017/019799 WO 20170202
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; A61L27/22 ; A61L27/18 ; A61L27/38 ; C12M3/00 ; C12M1/00 ; C12M1/12 ; A61L27/52 ; C08L83/04 ; A61L27/36
摘要：
The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.
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