Invention Grant
- Patent Title: Measuring reagent and analysis device for analyzing biopolymer
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Application No.: US15777326Application Date: 2016-10-20
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Publication No.: US10996211B2Publication Date: 2021-05-04
- Inventor: Yusuke Goto , Takahide Yokoi
- Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
- Applicant Address: JP Tokyo
- Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
- Current Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
- Current Assignee Address: JP Tokyo
- Agency: Mattingly & Malur, PC
- Priority: JPJP2015-251426 20151224
- International Application: PCT/JP2016/081061 WO 20161020
- International Announcement: WO2017/110226 WO 20170629
- Main IPC: G01N33/487
- IPC: G01N33/487 ; G01N27/447 ; G01N33/483 ; G01N15/10

Abstract:
An object of the present invention is to solve inhibition of biopolymer measurement in a nanopore, which involves three-dimensional conformation of a biopolymer containing a nucleic acid. The present invention provides a device for analyzing a biopolymer containing a nucleic acid, the device including: an array device including a plurality of thin film parts having a nanopore; a single common container and a plurality of individual containers capable of storing a measurement solution which is brought into contact with the thin films; and individual electrodes respectively provided in the plurality of individual containers, wherein: the measurement solution is introduced into each of the individual containers and the common container so as to be brought into contact with the thin films; and the measurement solution has a pH equal to or greater than pKa of a guanine base and contains cesium ions as electrolyte cations.
Public/Granted literature
- US20180335417A1 MEASURING REAGENT AND ANALYSIS DEVICE FOR ANALYZING BIOPOLYMER Public/Granted day:2018-11-22
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