Invention Grant
- Patent Title: Cell penetrating conjugates and methods of use thereof
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Application No.: US15056777Application Date: 2016-02-29
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Publication No.: US10967070B2Publication Date: 2021-04-06
- Inventor: Andreas Herrmann , Hua Yu , Piotr Marek Swiderski , John Ernest Shively , Lin Li
- Applicant: City of Hope
- Applicant Address: US CA Duarte
- Assignee: City of Hope
- Current Assignee: City of Hope
- Current Assignee Address: US CA Duarte
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: A61K47/50
- IPC: A61K47/50 ; C07K16/08 ; C07K16/40 ; C07K16/18 ; A61K39/44 ; A61K47/68 ; A61K47/54 ; A61K39/00 ; A61K38/00 ; C12N15/11
Abstract:
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
Public/Granted literature
- US20160317671A1 CELL PENETRATING CONJUGATES AND METHODS OF USE THEREOF Public/Granted day:2016-11-03
Information query
