Disclosed is a multi-angle adaptive intra-frame prediction-based point cloud attribute compression method. A novel block structure-based intra-frame prediction scheme is provided for point cloud attribute information, where six prediction modes are provided to reduce information redundancy among different coding blocks and improve the point cloud attribute compression performance. The method comprises: (1) inputting a point cloud; (2) performing point cloud attribute color space conversion; (3) dividing a point cloud by using a K-dimensional (KD) tree to obtain coding blocks; (4) performing block structure-based multi-angle adaptive intra-frame prediction; (5) performing intra-frame prediction mode decision; and (6) performing conversion, uniform quantization, and entropy encoding.