The present disclosure is directed to a method and device for automatically predicting FFR based on images of vessel. The method for automatically predicting FFR based on images of a vessel. The method comprises a step of receiving the images of a vessel acquired by an imaging device. Then, a sequence of flow speeds at a sequence of positions on a centerline of the vessel is acquired by a processor. A sequence of first features at the sequence of positions on a centerline of the vessel are acquired by the processor, by fusing structure-related features and flow speeds and using a convolutional neural network. Then, a sequence of FFR at the sequence of positions is determined by the processor through using a sequence-to-sequence neural network on the basis of the sequence of first features.