- 专利标题: Device for the analysis of nucleic acid molecules
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申请号: US15571679申请日: 2016-05-06
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公开(公告)号: US10933416B2公开(公告)日: 2021-03-02
- 发明人: Vincent Croquette , David Bensimon , Jimmy Ouellet , Jean-François Allemand , Charles Andre , Gordon Hamilton
- 申请人: Paris Sciences Et Lettres—Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , Universite Paris Diderot Paris 7 , Sorbonne Universite
- 申请人地址: FR Paris; FR Paris; FR Paris; FR Paris
- 专利权人: Paris Sciences Et Lettres—Quartier Latin,Centre National de la Recherche Scientifique (CNRS),Universite Paris Diderot Paris 7,Sorbonne Universite
- 当前专利权人: Paris Sciences Et Lettres—Quartier Latin,Centre National de la Recherche Scientifique (CNRS),Universite Paris Diderot Paris 7,Sorbonne Universite
- 当前专利权人地址: FR Paris; FR Paris; FR Paris; FR Paris
- 代理机构: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- 优先权: EP15305710 20150507
- 国际申请: PCT/EP2016/060155 WO 20160506
- 国际公布: WO2016/177869 WO 20161110
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; B01L3/00 ; C12Q1/6825 ; G01N27/327 ; G01N27/07
摘要:
The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.
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