A central plant optimization system for designing and operating a central plant includes a planning tool, a central plant controller, and an optimization platform. The planning tool is configured to generate a model of the central plant. The central plant controller is configured to receive the model of the central plant from the planning tool and combine the model of the central plant with timeseries data including a timeseries of predicted energy loads to be served by equipment of the central plant. The optimization platform is configured to receive the model of the central plant combined with the timeseries data, construct an optimization problem using the model of the central plant and the timeseries data, solve the optimization problem to determine an optimal allocation of the energy loads across the equipment of the central plant, and provide optimization results to the central plant controller. The central plant controller is configured to use the optimization results to operate the equipment of the central plant to achieve the optimal allocation of the predicted energy loads.