An apparatus for inspecting the integrity of a seal of a package that includes a container and a seal membrane carried by the container. The apparatus comprises a conveyor configured to move the sealed package along a path and including a vacuum plenum section configured to create a sub-atmospheric pressure that is applied to the seal membrane of the sealed package as the package moves through the vacuum plenum section. The apparatus further comprises an imaging sensor configured to generate one or more images of the seal membrane following the application of a sub-atmospheric pressure thereto at the vacuum plenum section. The apparatus still further comprises an electronic processing device configured to process the one or more images of the seal membrane generated by the imaging sensor, and to evaluate the integrity of the seal of the package based on the one or more images.