- 专利标题： Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
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申请号： US15863634申请日： 2018-01-05
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公开(公告)号： US10894063B2公开(公告)日： 2021-01-19
- 发明人: Seth Wardell , James Bender , Michael T. Lotze
- 申请人： Iovance Biotherapeutics, Inc.
- 申请人地址： US CA San Carlos
- 专利权人： Iovance Biotherapeutics, Inc.
- 当前专利权人： Iovance Biotherapeutics, Inc.
- 当前专利权人地址： US CA San Carlos
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： C12N5/06
- IPC分类号： C12N5/06 ; A61K35/17 ; A61K38/20 ; A61K31/675 ; A61K31/7076 ; A61P35/00 ; A61K9/00 ; A01N1/02 ; C12N5/078 ; C12N5/0783
摘要：
The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
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