Invention Grant
- Patent Title: Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use
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Application No.: US16483989Application Date: 2018-02-06
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Publication No.: US10889587B2Publication Date: 2021-01-12
- Inventor: Akash Jain , Evan Hecker , Richard Edwards , Thierry Bonnaud
- Applicant: SPERO THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: SPERO THERAPEUTICS, INC.
- Current Assignee: SPERO THERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Cantor Colburn LLP
- International Application: PCT/US2018/017067 WO 20180206
- International Announcement: WO2018/145089 WO 20180809
- Main IPC: C07D477/20
- IPC: C07D477/20 ; A61K45/06 ; A61P31/04

Abstract:
The disclosure is directed to new crystalline tebipenem pivoxil salt forms, including a crystalline tebipenem pivoxil ethane sulfonate salt form (Form A), a crystalline tebipenem pivoxil ketoglutarate salt form (Form A), tebipenem pivoxil maleate salt forms (Form A and Form B), a tebipenem pivoxil malate salt form (Form A), a tebipenem pivoxil methane sulfonate salt form (Form B), a tebipenem pivoxil hydrobromide salt form (Form B), and a tebipenem pivoxil edisylate salt form (Form A). The disclosure also includes a composition, comprising a crystalline tebipenem pivoxil salt and a pharmaceutically acceptable carrier and further includes a method for treating an antibiotic resistant bacterial infection, comprising administering to a patient in need of such treatment a therapeutically effective amount of a crystalline tebipenem pivoxil salt.
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