A display panel driving device includes a control signal generator which outputs a driving control signal, a driving unit which receives the driving control signal to output a panel driving signal, a protection circuit unit which receives a feedback current from the control signal generator and compares the feedback current with a reference current to perform a protection operation based on a result of comparison of the feedback current with the reference current, a temperature sensor which senses an ambient temperature, a controller which outputs a selection signal variable depending on the sensed ambient temperature, and a protection operation setting unit which sets a condition of the protection operation in response to the selection signal.