Invention Grant
- Patent Title: Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
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Application No.: US16583869Application Date: 2019-09-26
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Publication No.: US10696676B2Publication Date: 2020-06-30
- Inventor: Yam B. Poudel , Sanjeev Gangwar , Prasanna Sivaprakasam , Shoshana L. Posy
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D473/18
- IPC: C07D473/18 ; A61P37/04
Abstract:
Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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