Disclosed are a gate driving circuit of an irregular screen panel and a driving method. The gate driving circuit comprises: a first array substrate row driving circuit driving a scan line, which extends from the left side of the notch area to the notch area; a second array substrate row driving circuit driving a scan line, which extends from the right side of the notch area to the notch area; a third array substrate row driving circuit driving a scan line, which extends from the left side of the non-notch area to a right side thereof, and a scan line driven by a fourth array substrate row driving circuit is between adjacent scan lines driven by the third array substrate row driving circuit; the fourth array substrate row driving circuit driving a scan line, which extends from the right side of the non-notch area to the left side thereof.